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KMID : 0043320120350030415
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Archives of Pharmacal Research
2012 Volume.35 No. 3 p.415 ~ p.421
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A new flavonol glycoside from Hylomecon vernalis
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Lee Seung-Young
Kim Ki-Hyun
Lee Il-Kyun
Lee Kyu-Ha
Choi Sang-Un
Lee Kang-Ro
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Abstract
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Purification of a MeOH extract from the aerial parts of Hylomecon vernalis Maxim. (Papaveraceae) using column chromatography furnished a new acetylated flavonol glycoside (1), together with twenty known phenolic compounds (2?21). Structural elucidation of 1 was based on 1D- and 2D-NMR spectroscopy data analysis to be quercetin 3-O-[4?-O-acetyl-α-L-arabinopyranosyl]-(1?→6″)-β-D-galactopyranoside (1). The structures of compounds 2?21 were elucidated by spectroscopy and confirmed by comparison with reported data; quercetin 3-O-[2?-O-acetyl-α-L-arabinopyranosyl]-(1?→6″)-β -D-galactopyranoside (2), quercetin 3-O-α-L-arabinopyranosyl-(1?→6″)-β-D-galactopyranoside (3), quercetin 3-O-β -D-galactopyranoside (4), kaempferol 3,7-O-α-L-dirhamnopyranoside (5), diosmetin 7-O-β -D-glucopyranoside (6), diosmetin 7-O-β -D-xylopyranosyl-(1?→6″)-β-D-glucopyranoside (7), p-hydroxybenzoic acid (8), protocatechuic acid (9), caffeic acid (10), 6-hydroxy-3,4-dihydro-1-oxo-β -carboline (11), (Z)-3-hexenyl-β -D-glucopyranoside (12), (E)-2-hexenyl-β -D-glucopyranoside (13), (Z)-3-hexenyl-α-Larabinopyranosyl-(1″→6′)-β-D-glucopyranoside (14), oct-1-en-3-yl-α-L-arabinopyranosyl-(1″→6′)-β-D-glucopyranoside (15), benzyl-β-D-apiofuranosyl-(1″→6′)-β-D-glucopyranoside (16), benzyl-α-L-arabinopyranosyl-(1″→6′)-β-D-glucopyranoside (17), benzyl-β-D-xylopyranosyl-(1″→6′)-β-Dglucopyranoside (18), 2-phenylethyl-α-L-arabinopyranosyl-(1″→6′)-β-D-glucopyranoside (19), 2-phenylethyl-β-D-apiofuranosyl-(1″→6′)-β-D-glucopyranoside (20), and aryl-β-D-glucopyranoside (21). Compounds 2-21 were isolated for the first time from this plant. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.
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KEYWORD
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Hylomecon vernalis, Papaveraceae, Acetylated flavonol glycoside
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